• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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    • 专利摘要:
    invention patent: "nebulizer" the present invention relates to a nebulizer (1) comprising an insertable container (3) and a counter device (44) for counting operations of the nebulizer (1). the nebulizer (1) can be opened to replace the container (3). the counter device (44) blocks the opening of the nebulizer (1) until a predetermined number of operations have been reached.
    公开号:BR112012012475B1
    申请号:R112012012475-7
    申请日:2010-11-22
    公开日:2020-03-03
    发明作者:Jens Besseler；Holger Holakovsky；Markus Kaemper；Manuel Daelman；Gilbert Wuttke；Alexander Bach
    申请人:Boehringer Ingelheim International Gmbh；
    IPC主号:
    专利说明:

    Descriptive Report of the Invention Patent for NEBULIZER.
    [001] The present invention relates to a nebulizer according to the preamble of claim 1.
    [002] A starting point for the present invention is a nebulizer illustrated in WO 2006/125577 A2. The nebulizer comprises, as a reservoir for the fluid to be atomized or nebulizer, a rigid insertable container having an internal bag containing the fluid and a pressure generator with an actuation spring for the delivery and atomization of the fluid. Preferably, the container is protected against removal. For this purpose, the nebulizer in your housing can be designed in such a way that it cannot be opened after the container has been inserted.
    [003] Preferably, the container is pre-installed in the nebuliser on delivery. In particular, the pre-installed container is held by a non-movable conduit lock inside the housing in the delivery condition, in order to avoid any unwanted opening of the container.
    [004] Before being used for the first time, the nebulizer is completely closed. Thus, the pre-installed container is opened by a supply tube piercing a seal and a septum to fluidly connect to the inner bag of the container. In addition, the conduction lock is opened so that the container can move back and forth inside the nebuliser.
    [005] By turning the part of the lower housing of the nebulizer the actuation spring can be placed under tension and the fluid can be sucked into a compression chamber of the pressure generator. Simultaneously, the container is moved into the lower housing part in a pouring motion into the nebulizer and when tensioned, the container can be perforated for the first time
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    2/36 through its base by a piercing element in the lower housing part to allow ventilation of the container. After the manual operation of a locking element the actuation spring is released and the fluid in the pressure chamber is placed under pressure by the actuation spring and is supplied or atomized through a nozzle in a plug like an aerosol, without the use of propellant gas.
    [006] WO 2007/022898 A2 describes a similar nebulizer. A container can be inserted into a nebulizer housing. The housing is closed by a piece of the lower or bottom housing. The container is moved axially back and forth during conduction of the fluid to be nebulized during pressure generation and / or during nebulization. A counter device can be arranged on the housing part. The counter device locks the nebulizer against further use if a predetermined number of operations has been reached or exceeded. Then, the housing part can be replaced together with the counter device and the container. The container can be connected inseparably with the housing part. In addition, the nebulizer comprises a monitoring device to permanently block the nebulizer when a certain number of containers have been used, or when a certain number of operations have been reached.
    [007] The purpose of the present invention is to provide a nebulizer that can be used only with a predefined number of replaceable containers in which a simple construction is possible and / or a defined treatment is achieved.
    [008] The above objective is achieved by a nebulizer according to claim 1. The preferred modalities are the subject of the dependent claims.
    [009] The present invention relates to a nebulizer that can be opened for the insertion and replacement of a container with the fluid
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    3/36 to be nebulized. The nebulizer comprises a counter device for counting operations of the nebulizer. The counter device blocks the opening of the nebulizer until a predetermined number of operations has been reached or exceeded. Thus, it is possible to prevent the nebulizer from being opened before the container has been (sufficiently) used or has been emptied. Thus, the potential dirt of the nebulizer can be minimized and / or defined handling can be protected.
    [0010] The nebulizer or counter device is preferably constructed in such a way that the empty or used container is blocked against reuse and / or reconnection with the nebulizer. Thus, the reuse of an already used container can be avoided.
    [0011] Preferably, the nebulizer comprises a part of the lower housing that can be removed for opening the nebulizer and replacing the container. In particular, the counter device is arranged at the bottom of the housing and the container cannot be separated from the lower housing part so that these components must be replaced when the container is replaced. Thus, it is easy to avoid using an already used container since it cannot be reused, due to its associated counter device.
    [0012] Advantages, features, characteristics and additional aspects of the present invention will become apparent from the claims and the following description of a preferred embodiment, with reference to the drawings. He shows:
    [0013] figure 1 is a schematic section of a known nebulizer in a non-tensioned state;
    [0014] figure 2 is a schematic section, rotated through 90 ° in comparison with figure 1, of the known nebulizer in a tensioned state;
    [0015] figure 3 is a schematic section of a nebulizer in
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    4/36 a delivery status with a partially closed housing and a closed pre-installed container;
    [0016] figure 4 is a schematic section of the nebulizer according to figure 3 in a tensioned activated state, with the housing completely closed and with the container open;
    [0017] figure 5 is a schematic section of the nebulizer according to figure 4 in a non-tensioned state;
    [0018] figure 6 is a schematic section of a nebulizer with a partially closed housing and with a fixing means on a part of the housing keeping a container immobile in the nebulizer;
    [0019] figure 7 is a perspective view of the nebulizer fixation means according to figure 6;
    [0020] figure 8 is a side view of the nebulizer fixation means according to figure 6 keeping the associated container immobile;
    [0021] figure 9 is a partial schematic view of a part of the nebulizer according to figure 6 with an attachment means open so that the container can move;
    [0022] figure 10 is a schematic section of a housing part with an associated counter device and an associated nebulizer container in accordance with the present invention;
    [0023] figure 11 is a perspective view of a control device control ring;
    [0024] figure 12 is a perspective view of a control element of the counter device;
    [0025] figure 13 is a partial sectional view of the nebulizer without the housing part, the counter device and the container; and [0026] figure 14 is a partial view of a part of the nebulizer interacting with the control ring of the counter device.
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    5/36 [0027] In the figures, the same reference numbers have been used for identical or similar parts, resulting in corresponding or comparable properties and advantages, even if the associated description is not repeated.
    [0028] Figures 1 and 2 show a nebulizer 1 known for atomizing a fluid 2, especially a highly effective or similar pharmaceutical composition, schematically shown in a non-tensioned state (figure 1) and in a tensioned state (figure 2). Nebulizer 1 is constructed in particular as a portable inhaler and preferably works only mechanically and / or without propellant gas.
    [0029] When fluid 2, preferably a liquid, more particularly a pharmaceutical composition, is nebulized, an aerosol 14 (figure 1) is formed, which can be breathed or inhaled by a user. Generally, inhalation is done at least once a day, more particularly, several times a day, preferably at defined intervals, depending on the disease or complaint from which the patient suffers.
    [0030] Nebulizer 1 is provided with or comprises an insertable container 3 containing fluid 2. Container 3 thus constitutes a reservoir for fluid 2, which is to be nebulized. Preferably, container 3 contains an amount of fluid 2 or the active substance which is sufficient to supply up to 200 dosage units, for example, that is, to allow up to 200 sprays or applications. A typical container 3, as described in WO 96/06011 A1, for example, contains a volume of about 2 to 10 ml.
    [0031] The container 3 is substantially cylindrical or in the form of a cartridge and once the nebulizer 1 has been opened the container can be inserted into it from below and changed if desired. It is preferably of rigid construction, fluid 2, in particular to be maintained 870190092754, of 09/17/2019, p. 8/50
    6/36 in a collapsible bag 4 in container 3.
    [0032] The nebulizer 1 preferably comprises a pressure generator 5 for the conduction and nebulization of the fluid 2, particularly in a predefined and optionally adjustable dosage amount. The pressure generator 5 preferably comprises a support 6 for the container 3, an associated driving spring 7, only partially shown, a locking element 8, which can be operated manually to release the spring 7, a driving element such as such as a conduction tube 9, a non-return valve 10, a pressure chamber 11 and / or a nozzle 12 for nebulizing the fluid 2 into a nozzle 13. The container 3 is fixed or maintained in the nebulizer 1 through the support 6 such that the guide tube 9 penetrates the container 3. The support 6 can be constructed so that the container 3 can be exchanged.
    [0033] As the actuation spring 7 is axially tensioned the support 6 with the container 3 and the conduction tube 9 is moved downwards in the drawings and the fluid 2 is sucked out of the container 3 to the pressure chamber 11 pressure generator 5 via non-return valve 10 (fluid conduction 2, suction stroke). Next, nebulizer 1 is in the so-called activated or tensioned call state.
    [0034] During the subsequent relaxation after activation of the locking element 8, the fluid 2 in the pressure chamber 11 is placed under pressure, as the conduction tube 9 with its now closed non-return valve 10 is moved back upwards by the relaxation of the actuation spring 7 and now acts as a pressing or piston branch (pressure generation and / or fogging). This pressure forces the fluid 2 through the nozzle 12, after which it is nebulized to the aerosol 14, as shown in figure 1.
    [0035] Generally, nebulizer 1 operates at a pressure of
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    7/36 spring from 5 to 200 MPa, preferably from 10 to 100 MPa over fluid 2, and / or with a volume of fluid 2 delivered per stroke from 10 to 50 pl, preferably 10 to 20 pl, more preferably about 15 pl. Fluid 2 is converted to or nebulized as an aerosol 14, the droplets of which have an aerodynamic diameter of up to 20 pm, preferably 3 to 10 pm. Preferably, the generated spray jet has an angle of 20 ° to 160 °, preferably 80 ° to 100 °. These values are also applicable for nebulizer 1 according to the teaching of the present invention as particularly preferred values.
    [0036] A user (not shown) can inhale aerosol 14, while an air source can be aspirated into the plug 13 through at least one opening of the air source 15.
    [0037] Preferably, nebulizer 1 can be manually activated or tensioned. The nebulizer 1 preferably comprises a part of the upper housing 16 and an internal part 17 which is rotatable with respect to it (figure 2) having an upper part 17a and a lower part 17b (figure 1), while one in particular manually operable (bottom) housing part 18 is releasably attached, particularly mounted on the inner part 17, preferably by means of a retaining element 19. Preferably, housing parts 16 and 18 form a housing for nebulizer 1. A in order to insert and / or replace the container 3 the housing part 18 can be detached from the nebulizer 1 or its housing.
    [0038] The housing part 18 can be rotated in relation to the upper housing part 16, carrying with it the part 17b of the inner part 17. As a result, the actuation spring 7 is tensioned in the axial direction by means of a gear or transmission (not shown) acting on the support 6. During tensioning, container 3 is moved axially downward until container 3 takes a final position, as shown in figure 2. In this state
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    8/36 activated or tensioned the actuation spring 7 is under tension. During the nebulization process, the container 3 is moved back to its original position (position or untensioned state shown in figure 1) by the actuation spring 7. Thus, the container 3 performs a lifting or stroke movement during the process of tensioning and during the atomization process.
    [0039] The housing part 18 preferably forms a lower housing part similar to the lid and fits around or through a free lower end part of the container 3. As the actuation spring 7 is tensioned the container 3 moves with its end part (additional) towards the housing part 18 or towards the end face thereof, while an aeration means, such as an axially acting spring 20 arranged in the housing part 18, comes in contact with the base 21 of the container 3 and pierces the container 3 or a base seal on it with a perforating element 22 when the container 3 makes contact with it, for the first time, to allow air entry or aeration .
    [0040] The nebulizer 1 may comprise a monitoring device 23, which counts the drives of the nebulizer 1, preferably by detecting the rotation of the internal part 17 in relation to the upper part 16 of the housing. Preferably, the monitoring device 23 blocks the actuation or use of the nebulizer 1, for example, it blocks the actuation of the locking element 8, when a number of actuations or discharges have been reached or exceeded.
    [0041] A preferred construction and mode of the inhaler or nebulizer 1 will now be described in greater detail with reference to figures 3 to 5, but emphasizing only essential differences from nebulizer 1 according to figures 1 and 2. The related observations
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    9/36 with figures 1 and 2, so they preferably apply accordingly or in a similar manner, while any desirable combinations of characteristics of nebulizer 1 according to figures 1 and 2 and of nebulizer 1 described below are possible .
    [0042] Figures 3 to 5 show, in schematic sectional views, a nebulizer 1 according to a slightly different modality. Figure 3 shows the nebulizer 1 in a delivery state, that is, with a pre-installed container 3, which is still closed. In this state, the nebulizer housing 1 is not completely closed, in particular, the housing part 18 is not fully pressed in the inner part 17. Figures 4 and 5 show the nebulizer 1 in an activated / or tensioned state with the housing completely closed and with container 3 open. In figure 4, the nebulizer 1 or spring unit 7 is tensioned, that is, the container 3 is in its lower position. Figure 5 shows the nebulizer 1 in a non-tensioned state, for example, after delivery or discharge of a dose of fluid 2, the container 3 is in its upper position.
    [0043] The container 3 is already assembled or pre-installed in the nebulizer 1 in the delivery state, as shown in figure 3. In this state, the container 3 is still closed, that is, there is no fluid connection between the container 3, or its bag 4, on the one hand and the nebulizer 1 or its pressure generator 5 or the driving element, on the other hand.
    [0044] The container 3 comprises a fluid outlet 24 for the fluid outlet 2 to be dispensed. In particular, the fluid outlet 24 allows a fluid connection between the container 3, or its bag 4, on the one hand and the nebulizer 1, its pressure generator 5 or the driving element, on the other hand.
    [0045] The fluid outlet 24 has an internal closure 25 which is pre
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    10/36 formed by a septum, a membrane, a plastic seal or the like and / or is provided inside the container 3. Optionally, a second or external closure 26 can be provided to cover and / or close the fluid inlet 24.
    [0046] Preferably, the closures 25 and 26 are designed so that successive opening is possible by means of a common element, in particular the conducting element of or conduction tube 9 or the like, and / or by drilling.
    [0047] In the preferred embodiment, the first closure 25 and second closure 26 are arranged one after the other and / or spaced in the axial direction or in the direction of the movement of the travel of the container 3, or in relation to the direction of the main outlet of the fluid 2 .
    [0048] Generally, the container 3, the fluid outlet 24 or closures 25 or 26 are opened in particular by means of a conducting element, such as the conduction tube 9, or the like and / or by drilling or in any other properly. In particular, the opening is achieved by moving the container 3 in relation to the nebulizer 1 or conducting element or tube 9 or the like and / or by moving in the longitudinal or axial direction.
    [0049] Preferably, the first closure 25 is formed or supported by a closure part 27 which extends from the outlet end or the head of the container 3 into the container 3 or bag 4. The second closure or outer 26 is preferably located adjacent to the head or axial end of the container 3 and / or maintained or attached to a flange 28, which can be formed by the closure part 27 or any other suitable part. However, other construction solutions are possible.
    [0050] In the delivery state according to figure 3, the container 3 has been pre-installed, that is, inserted into the nebulizer 1. However, the container 3 or its fluid outlet 24 is not yet open. In pair
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    11/36, the second latch 26 is open, but not the first latch 25. This is achieved, in particular where the housing of nebulizer 1 is closed only partially, that is, not completely, in the delivery state, preferably not closing or pushing the housing part 18 completely, as shown. Preferably, the housing part 18 is fitted over or only partially inserted in the delivery condition.
    [0051] In particular, the container 3 is connected to or maintained by or fixed to the housing part 18, in particular by a conduit lock 29, which is preferably arranged inside or in a housing part 18. The transport lock 29 maintains the container 3, preferably temporarily, in particular before attaching the housing part 18 to the nebulizer 1 and / or in the delivery state. In particular, the transport lock 29 keeps the container 3 fixed during the fluid connection of the container 3 and / or during the mechanical connection of the container 3, here with the support 6. Preferably, the transport lock 29 keeps the container 3 fixed during opening, in particular, drilling, container 3.
    [0052] In the delivery state, where the nebulizer 1 can be sent or delivered to the user or is still packaged, the nebulizer 1 or the housing part 18 is preferably fixed, in particular by means of a fixing member 30, in such a way that the container 3 and / or the housing of the piece 18 are kept sufficiently spaced from the nebulizer 1 or part of the upper housing 16 and / or prevented from being completely inserted or pushed over the element or the conduction tube 9, the housing or the part of the inner housing 17 or the like and / or such a (complete) opening of the container 3, namely, of the first closure 25, is prevented.
    [0053] In the embodiment shown, the fixing member 30 is preferably mounted between the housing part 18 and the housing part
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    12/36 upper groove 16 and preferably engages with or between housing parts 16 and 18, so that the housing part or lower part 18 is axially fixed or is kept or supported sufficiently spaced or spaced from the upper housing part 16 to be able to keep the (still) closed container 3 or the first closure 25 away from the conduction tube 9.
    [0054] In the preferred embodiment, the fixing member 30 is at least substantially hollow and / or cylindrical and is arranged axially between the housing part (lower) 18 and the housing part 16. To activate the nebulizer 1 or prepare yours for use, that is, to push the housing part 18 fully in the axial direction and thus open the container 3, the fixing member 30 must first be removed or released or opened. In the preferred embodiment shown, the fixing member 30 is constructed in the form of a flag or the like, made of plastic, for example, and / or can be manually opened, removed or destroyed. The fixing member 30 may alternatively or simultaneously form or constitute an original seal. However, other embodiments of the fixing member 30 are also possible, for example, in the form of a security tag or the like.
    [0055] Preferably, the container 3 and / or the housing part 18 are maintained positively or in a form of adjustment in the form or interlock in the state of delivery. This is achieved in the preferred embodiment, in particular by means of the locking lock 29 that acts between the container 3 and the housing part 18, and the fixing member 30 acting between the housing part 18 and the nebulizer housing 1 or upper housing part 16 or similar. However, the guide lock 29 or the fixing member 30 can also act directly between the container 3 on the one hand and the nebulizer 1, its housing, the upper housing part 16, the housing part
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    13/36 internal 17 or support 6, on the other hand.
    [0056] The pre-installed container 3, that is, its first closure 25, is still closed in the delivery state, ie, not activated state with the pre-installed container 3.
    [0057] In order to secure the housing part 18, it can be fixed in the state of delivery by means of at least one coupling projection 31, the projection, the nose or the like, which engages in an associated locking recess 32 in housing part 18 or similar. The locking tab 31 can be formed by or on a locking arm 33, which is preferably flexible.
    [0058] Once the safety member 30 has been removed a user (not shown) can push the housing part 18 fully in the axial direction and thus open the container 3, that is, the first lock 25, inserting the element pipe or pipe 9. Figures 4 and 5 show this activated state with housing part 18 pushed completely over and / or container 3 open (fluidly connected to nebulizer 1 or its pressure generator 5 or the element or the conduction tube 9). In this pushed or activated state, the housing part 18 is preferably fixed or axially fixed by interlocking engagement, that is, in the form of shape adjustment in the axial direction, particularly by engaging the retaining element 19 or the like, but can be highlighted if desired.
    [0059] Figure 4 shows nebulizer 1 or container 3 in the activated state, container 3, that is, first closure 25, is opened, that is, container 3, or its fluid 2 is fluidly connected to nebulizer 1 or to its pressure generator 5, and the housing part 18 has been pushed fully in the axial direction. In order to bring support 6 (complete) in engagement with container 3 at the end of the head and then be able to move container 3 back and / or forward, for suction / tensioning and pressing the stroke, can be ne
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    14/36 it is necessary to intend nebulizer 1 or to conduct spring 7 for the first time. During this tensioning process the support 6 is moved together with the guide tube 9 axially in the direction or in the housing part 18, thus bringing support 6 (complete) in engagement with the container 3 and preferably also in movement or by pressing the container 3 against the piercing element 22 in the region of the base of the housing part 18 and, thus, drilling a hole or ventilation opening 34 in the base of the container 21. Figure 4 shows the nebulizer 1 in this tensioned and activated state. The support 6 is wrapped with the container 3 and the conduction tube 9 has been fully inserted in the container 3.
    [0060] Figure 5 shows the nebulizer 1 in a relaxed, non-tensioned state, that is, after the atomization or discharge of a dose of fluid 2. The support 6 and the container 3 are in the upper position. The support 6 is still involved with the container 3 and remains engaged during the subsequent uses of the nebulizer 1. Furthermore, the container 3 is still open and fluidly connected, that is, the nebulizer 1 remains activated.
    [0061] Nebulizer 1 is activated after removal of the fixing member 30 and (total) axial pushed from the housing part 18 and can be used in the same way as nebulizer 1 shown in figures 1 and 2.
    [0062] To avoid unwanted opening of the container 3, particularly the first closure 25, in the delivery state of the nebulizer 1, preferably the transport lock 29 is provided. By friction, forced or interlocking, for example, the transport lock 29 prevents the container 3 from moving undesirably axially in the nebulizer 1, for example, during transport, in case of accidental fall of the nebulizer 1 or similar.
    [0063] Preferably, the opening of the transport lock 29 occurs
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    15/36 automatically when the nebulizer 1 or its housing is closed completely, that is, when bouncing or pushing the housing part 18 completely towards the upper housing part 16. During this closing movement (axial or telescopic), the transport lock 29 is opened and the container 3 is released in the axial direction, preferably only in the last part of the movement and / or just before the fully closed end position is reached or only when the final fully closed position is reached.
    [0064] During the closing movement of the transport lock 29, it is preferably opened by direct or indirect interaction with or actuation by the nebulizer housing 1, the inner part 17 or its lower parts 17b, a bearing ring 43, holding spring 7 or the like. Preferably, the container 3 and / or the first closure 25 are opened, as well as the transport lock 29 by means of a common actuation, here the closing movement of the nebulizer 1 or its housing or the lower part 18.
    [0065] Figures 4 and 5 show the conduction lock 29 in the open position, that is, in which the container 3 is free to move axially.
    [0066] Preferably, in the non-activated state, that is, when the housing part 18 has not been pushed over the nebulizer 1 completely, it can be blocked to prevent tensioning of the pressure generator 5, that is, in particular to avoid the rotation of the inner part 17 relative to the upper housing part 16. This can be important when the nebulizer 1 is delivered in the delivery condition with the pressure generator 5 not energized. Therefore, the inhaler 1 can have a barrier, so that the inner part 17 can only be rotated in relation to the upper housing part 16, when the housing part 18 has been pushed fully connected
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    16/36 da. Alternatively or additionally, the fixing member 30 can lock not only by pushing the lower part 18 in the delivery state, but also any rotation of the inner part 17 until the fixing member 30 has been opened, released or removed.
    [0067] In what follows, additional aspects of the inhaler or nebulizer 1 will be described in detail with reference to figures 6 to 9, in which only essential differences will be emphasized so that the previous observations and explanations referring to nebulizer 1, according to the Figures 1 to 5, preferably apply in a corresponding or similar manner.
    [0068] Figure 6 shows in a partially schematic, partially sectional view, nebulizer 1 in the delivery state with no housing completely closed or housing of part 18. However, the housing part 18 has already been pushed over the inner part 17 more than initially supplied in the delivery condition, as shown in figure 3. Consequently, the container 3 has already been opened in the state shown in figure 6. In addition, the fixing member 30, which preferably fixes the housing part 18 , in the state of delivery against pushing the inner part 17, has already been released or opened or removed in the state shown in figure 6.
    [0069] The nebulizer 1 or its housing comprises a fixing means 35 to support the container 3 such that the container 3 is movable back and forth for the conduction of the fluid 2, the generation of pressure and / or nebulization , but it is inseparable from the housing part 18, and / or in such a way that the container 3 is held immobile in the delivery state of the nebulizer 1.
    [0070] The fixing means 35 is located or preferably arranged in or in the housing part 18, as shown in figure 6.
    [0071] Figure 7 shows in perspective a preferred embodiment of the fixing means 35. Figure 8 shows the means of fixing
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    17/36 fixture 35 connected with container 3.
    [0072] Preferably, the fixing means 35 comprises or consists of a metal and / or stamping piece and / or consists of a single, unitary piece, as shown in figure 7.
    [0073] Preferably, the fixing means 35 is made of steel in particular, spring steel.
    [0074] Preferably, the fixing means 35 is produced from sheet material by cutting, stamping or the like and / or by bending.
    [0075] Preferably, the fixing means 35 or the part forms a cage, in particular, comprises the container 3 or an end part thereof.
    [0076] Preferably, the fixing means 35 comprises support elements 36 and / or locking elements 37. The locking elements 36 and 37 are preferably designed as arms, fingers, leaves or the like. In particular, the elements 36, 37 are alternately distributed over a circumference of the container 3 and / or extend at least essentially axially or in the direction of the backward and forward movement of the container 3.
    [0077] Preferably, elements 36 and 37 are held by or attached to a base 38 of the fixing means 35.
    [0078] Preferably, the fixing means 35 or base 38 comprises or stops the piercing element 22 to pierce the container 3, i.e., the opening of the base of the container 21, or its ventilation hole 34 in the activated and tensioned state , that is, when the container 3 reaches its lowest final position. In the embodiment shown, the piercing element 22 is formed by a respective fold of a spring part 39 of the fixing means 35 or its base 38. The spring part 39 can support or facilitate the connection (complete or final) of the container 3 support 6.
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    18/36 [0079] The fixing means 35 or base 38 preferably comprises at least one or more fixing portions 40 to fix the fixing means 35 to either nebulizer 1 or the housing or housing part 18 In particular, the fixing portions 40 can fix the fixing means 35 when the fixing means 35 is pressed into the housing part 18, cooperating with the side wall of the housing part 18. However, it is also possible to overmould the fixing means 35, its base 38, the fixing portions 40 or the like. In addition, the fixing means 35 could be connected with the housing part 18 or the like, in any other suitable way.
    [0080] Preferably, the fixing means 35 not only prevents the separation of the container 3 from the nebulizer 1, its housing part or housing 18, but also forms the transport lock 29 to hold the container 3 immobile in the housing , in the delivery state of the nebulizer 1. Figures 6 and 8 show this state or situation when the container 3 is held immobile (axially) by the fixing means 35, that is, when the transport lock 29 is closed. In this situation, the container 3 or its radially protruding end or edge 41 of the container 3 is maintained between the support element 36 and the locking element 37 and, in particular between the respectively formed or folded ends of the elements 36 and 37.
    [0081] In the embodiment shown, the end of the container or edge 41 is secured between the end portions 36a and 37a of elements 36 and 37. The support element 36 holds or extends along edge 41 and the locking elements 37 or its end portions 37a adhere or extend under the edge 41 or the base of the container 21 so that the edge 41 and the container 3 are firmly secured preventing any axial movement of the container 3
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    19/36 in relation to the fixing means 35 and in relation to the associated housing part 18, in this state, that is, with fixing means 35 / transport lock 29 blocked.
    [0082] The retaining element 36 and the locking elements 37 are distributed alternately around the container 3 or edge 41.
    [0083] Preferably, the end portions 36a of the final support elements 36 in one radial first plane and the end portions 37a of the final locking element 37 in another, radial second plane, in which the two planes are axially displaced to holding edge 41 between and / or where the second plane is located axially between the first plane and the position of the lower end of the container 3 or the lower end of the housing part 18 or the piercing element 22. Additionally or alternatively, the portions end ends 36a over another radius (outer radius) than end portions 37a and / or axially spaced.
    [0084] The end portions 36a and / or 37a preferably form as claws or the like and / or extend radially inward, preferably.
    [0085] Preferably, elements 36 and / or 37 can flex with their free ends if radially outward.
    [0086] For example, the ends of the end portions 36a can be angled in such a way that the container 3 can be inserted or connected with the fixing means 35 by a respective axial force so that the elements that hold 36 flexible to outside, they allow the passage of edge 41. However, the support element 36 can also be flexed externally by a suitable tool (not shown) or similar when the container 3 is inserted, in particular with its edge 41, into the middle fastening 35.
    [0087] Preferably, the support elements 36 prevent the
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    20/36 removing the container 3 from the fixing means 35 and thus from the associated housing part 18 or similar.
    [0088] The locking element 37 or its final portions 37a can be flexed radially outwards in order to open the axial scan or transport lock 29 (this will be explained in detail with reference to figure 9, below). Thereafter, the container 3 can move axially, in particular back and forth and / or with its edge 41, between the foreground and the piercing element 22 in the present embodiment.
    [0089] In the present embodiment, the locking elements 37 comprise drive portions 37b (preferably formed at the free ends and / or between adjacent end portions 37a). Preferably, the drive portions 37b form axial extensions that can be displaced radially. The drive part 37b cooperates with an associated control element 42 or the multiple control members 42 of the nebulizer 1 such that the locking elements 37 are radially outward when flexed (completely) closing the housing to open the transport lock 29 (here mainly formed by the locking element 37 or its final portions 37a).
    [0090] Figure 6 shows schematically the control member 42 axially spaced from the associated drive part 37b as the housing has not yet been closed (completely).
    [0091] Figure 9 shows a lower part of the nebulizer 1 completely closed with opening of the transport lock 29, that is, radially outward with flexible locking elements 37. Figure 9 shows that the control member 42 has an inclined surface oriented or the like to convert the axial closing movement to the radial opening movement of the drive part 37b and thus of the associated locking element 37 to open the transport lock
    Petition 870190092754, of 17/09/2019, p. 23/50
    21/36
    29, in particular when the housing has been completely closed or when the housing part 18 has been pushed completely into the nebuliser 1.
    [0092] The control member 42 is preferably formed as an axial protrusion. It can be formed by or in ring 43, or any other means of support of the nebulizer 1 to counteract the actuation spring 7 on the inner part 17, or by or to any other suitable component of the nebulizer 1, such as the inner part 17 .
    [0093] The control member 42 can be formed as a protruding axial ring or shoulder or crest that extends along the ring 43.
    [0094] The control member 42 can additionally protect the support elements 36 against axial opening when the housing is completely closed, as shown schematically in figure 9. In this case, the control member 42 comes into contact with ( s) support element (s) 36 or their end portions 36a peripherally on the outer side to avoid any outward bending. Then, the fixing means 35 or 36 that hold its elements are protected against opening so that the container 3 is firmly held within the fixing means 35 or in the cage formed by the fixing means 35 or support elements 36.
    [0095] Figure 9 shows the container 3 in its lowest position when the perforating element 22 can drill the evacuation hole 34 or an associated seal connected to the base of the container 21.
    [0096] In the present embodiment, the fixing means 35 has several functions. It keeps container 3 (in the activated state / with the housing completely closed) in such a way that it can move back and forth, in particular during the transmission of fluid 2, during pressure generation and / or during nebulisation, in which the container 3 is inseparable from the housing or housing part 18. Furthermore, the fixing means 35 forms the transport lock 29 and / or
    Petition 870190092754, of 17/09/2019, p. 24/50
    22/36 keeps the container 3 immobile in the delivery state of the nebulizer 1. In addition or alternatively, the fixing means 35 comprises an opening means, here the perforating element 22, for opening the ventilation hole 34 of the container 3.
    [0097] Preferably, the fixing means 35 forms a cage, which cannot be separated from the container 3 after connecting with the container
    3.
    [0098] The transport lock 29 and the lock elements 37 are kept open during normal use of the nebulizer 1, in particular, since the housing is (completely) closed. When the housing is opened, that is, the housing part 18 is separated, the control member 42 can disengage from the drive portions 37b so that the locking element 37 can close or flex inwards again. Then, the locking elements 37 can clamp with their end portions 37a along the edge 41 of the container 3 such that an additional lock is formed, which prevents the container 3 from being detached from the fixing means 35 / housing part 18.
    [0099] The fixing means 35 avoids separating the container 3 from the housing part 18. Therefore, the container 3 can be replaced or exchanged only in conjunction with the housing part 18. [00100] In the following, a preferred embodiment of nebulizer 1 according to the present invention will be described with reference to figures 10 to 14. The foregoing observations and explanations of figures 1 to 9 apply preference in a corresponding or similar manner. Primarily, only essential differences or new aspects will be explained in detail. Nebulizer 1 is reusable, that is, it can be used with multiple containers 3 one after the other.
    [00101] Nebulizer 1 comprises a counter device 44 for counting operations of nebulizer 1. It is preferably if
    Petition 870190092754, of 17/09/2019, p. 25/50
    23/36 stopped from monitor device 23, even if the last one boosts the counter device 44 or vice versa.
    [00102] Counter device 44 blocks the opening of nebulizer 1 until a predetermined number of operations has been reached or exceeded. In particular, the counter device 44 is preferably associated with only one container 3 and the counting operations of the nebulizer 1 with the respective container 3, that is, counts (only) of the number of fluid doses 2 removed or even removable from of this container 3. Thus, the counter device 44 blocks the opening of the nebulizer 1 until a predetermined number of doses of fluid 2 has been designed or removed from the respective container 3. In other words, the counter device 44 counts the operations or uses of the respective container 3 in nebulizer 1 and blocks the opening of nebulizer 1 until a predetermined number has been reached or exceeded.
    [00103] Preferably, the counter device 44 is associated with or located in or in the container 3 and / or the housing part 18. Figure 10 shows in a schematic section of the housing part 18 of the nebulizer 1, in which the device counter 44 is connected to or located in the housing part 18, in particular, it cannot be separated from the housing part 18. The container 3 is preferably inseparable from the housing part 18 and thus from the device counter 44 or vice versa.
    [00104] The container 3 is preferably inseparably connected with the housing part 18 by means of the fixing means 35, as already discussed.
    [00105] In the embodiment shown, the counter device 44 preferably comprises a control means, in particular a control ring 45, which is shown separately in a perspective view in figure 11. The ring control or control means 45
    Petition 870190092754, of 17/09/2019, p. 26/50
    24/36 comprises an internal dentition 46, preferably a control recess 47, an unlock recess 48 and / or a preferably internal curve or ridge 49. Preferably, the control or control ring means 45 is rotatable and / or is indexed each time a usage operation is counted, for example, each time the nebulizer 1 is tensioned, the container 3 is moved, the fluid 2 is drawn from the container 3, the fluid 2 is nebulized, the actuation spring 7 pressurizes the fluid 2, or the like.
    [00106] The counter device 44 preferably comprises a control element 50 which is shown in figure 10 and in a perspective view in figure 12. The control element 50 is preferably associated with the control means or control ring 45. In the present embodiment, the control element 50 comprises a polarizing part 51, an engagement part 52 and / or a fixing part 53. In particular, the control element 50 is axially movable and / or guided by the workpiece accommodation 18.
    [00107] Preferably, the control element 50 can block the used container 3 and / or the housing part 18 against further use, reuse and / or reconnection with the nebulizer 1. Figure 10 shows the control element 50 in the initial, non-blocking position and the dashed line in the blocking position, that is, in the mode shown axially displaced and / or upwards and / or in the direction of the upper housing part 16 not shown in figure 10. In particular, the element control panel 50 protrudes in its locked position along the housing part 18 and / or towards the upper housing part 16.
    [00108] A support part 54, located here or formed by the housing part 18, or the like, cooperates with the lock part 53 in such a way that the control element 50 is locked in the locked position since the element control 50 reached the
    Petition 870190092754, of 17/09/2019, p. 27/50
    25/36 its locked position. In other words, the locking part 53 allows self-locking (irreversible) of the control element 50 in the locked position.
    [00109] The counter device 44 is preferably driven by the monitoring device 23 of the nebulizer 1. This will be explained in what follows before a detailed description of the operation of the counter device 44 below.
    [00110] Figure 13 shows in a partial schematic section of nebulizer 1 a preferred construction of the base of the monitoring device 23. In the present embodiment, the monitoring device 23 comprises a drive element, here a threaded shaft 55, with a pilot associated 56. During the rotation of the drive element or threaded shaft 55, the pilot 56 is axially movable in which the axial position of the pilot 56 corresponds to the total number of operations or drives of the nebulizer 1 and / or the number of containers 3.
    [00111] When the nebulizer 1 reaches or exceeds a predetermined value of operations or spraying, the monitoring device 23 or a driving part 57 the pilot 56 can block the nebulizer 1 against further operation or use, in particular by interlocking the internal part 17 with the upper part of the housing part 16 or vice versa. This is done, in the mode shown in that the driving part 57 of the pilot 56 cooperates with or drives a locking spring 58, in particular axially displaces the locking spring 58. The locking spring 58 is mounted in a pre-state - tensioned in such a way that it can expand radially and involve a radial recess or the like when the locking spring 58 or part of it is actuated or axially displaced (here by the pilot 56 or its actuation part 57) to block the nebulizer 1 or interlocking of its parts 16 and 17. In enPetição 870190092754, of 17/09/2019, p. 28/50
    26/36 so much, other construction solutions are also possible.
    [00112] The monitoring device 23 is preferably driven by the rotation of the internal part 17 in relation to the upper housing part 16, when the nebulizer is tensioned 1. In the present embodiment, the monitoring device 23, or its axis 55 is connected to or maintained from the inside 17. The monitoring device 17 or shaft 55 comprises a transmission gear 59, which meshes with the upper housing part 16, so that shaft 55 is rotated when the nebulizer 1 is tensioned or at inner part 17 is rotated in relation to the upper housing part 16. In particular, the transmission gear 59 is directly connected with or formed by the shaft 55. However, other construction solutions are also possible.
    [00113] Preferably, the tensioning of the nebulizer 1 or the rotation of the internal part 17 in relation to the housing part 16 also directs the counter device 44. In particular, the monitoring device 23 or the axis 55 drives the counter device 44 or its control member or control ring 45, preferably via a transmission gear 60. In the present embodiment, the shaft 55 is axially enlarged and / or the transmission gear 60 is connected with the shaft 55, so that the shaft 55 and / or transmission gear 60 extends to the lower housing part 18 and / or mesh with the control member or ring 45, in particular its tooth 46. This cooperation is shown schematically in the schematic view of a part of the nebuliser 1 and the control device or counter ring 44 45 in figure 14. The pilot 56, the locking spring 58, the upper housing part 16, the lower housing part 18 and the control element 50 are not shown in the figure
    14.
    [00114] The inner tooth 46 is preferably axially open, for
    Petition 870190092754, of 17/09/2019, p. 29/50
    27/36 allow an axial connection and disconnection with the associated transmission gear 60, as shown in figure 14.
    [00115] The counter device 44 blocks the opening of the nebulizer 1 until a predetermined number of operations (with the respective container 3) has been reached or exceeded. For this purpose, the lower housing part 18 is blocked, in particular in a shape-adjusting manner, against opening until the predetermined number has been reached or exceeded. This is achieved in the present embodiment, preferably by a hook-type lock member 61 associated with nebulizer 1 or its inner part 17, here connected to ring 43 or to the free or lower end of inner part 17. Preferably, the latch 61 is formed in a single form or by ring 43. However, other construction solutions are also possible.
    [00116] When the nebulizer housing 1 is completely closed, that is, the lower housing part 18 is completely pressed into the internal part 17, the nebulizer 1, in particular the locking member 61, preferably fits automatically with the part of the lower housing 18, the counter device 44, or its control ring 45. This can be achieved as the locking member 61 flexes radially, in particular inward due to the interaction of a respectively inclined guiding surface 62 with control ring 45 or crest 49. Then, once lock member 61 has passed control ring 45 or crest 49, it can flex back and adhere under control ring 45 or crest 49 so that nebulizer 1 or its housing is blocked against opening (this state is also called the blocking state or safe state).
    [00117] As shown schematically in figure 14, the locking member 61 fits with the control member or ring 45, in particular the ridges 49, so that the axial separation of the conPetition ring 870190092754, of 17/09/2019 , p. 30/50
    28/36 trolley 45, the counter device 44 and / or part of the lower housing 18 of the inner part 17, part of the upper housing 16 or the rest of the nebulizer 1 for opening the nebulizer 1 is not possible in this safe state blocking the opening of the nebulizer 1.
    [00118] As already mentioned, the control element or ring 45 is driven by the monitoring device 23 or axis 55, in particular by transmission gear 60 articulated with the toothed part 46. Thus, the control member or ring 45 is indexed nebulizer 1 is used or tensioned one step at a time. During this rotation of the control element or ring 45, the nebulizer 1 remains locked against the opening, in particular by the continuous engagement of the lock member 61 with the circumferentially extending pilot 49. When the predetermined number of operations is reached or exceeded, the recess The unlocking mechanism 48 reaches the locking member 61 and thus releases the nebulizer 1 so that the nebulizer 1 or its housing part 18 can be opened (axially pulled from the inside 17, in particular, when or after press the retaining element 19). This unlocking is possible because the unlocking recess 48 closes the shape-adjusting interlock of the locking member 61 with the control ring 45, or its crest 49 so that the locking member 61 can move through the recess to unlock 48 and pass ring 45 / ridge 49, when axially detaching the lower housing part 18, together with the counter device 44 and control ring 45.
    [00119] Preferably, the counter device 44 not only blocks the nebulizer 1 against opening until the predetermined number has been reached or exceeded, but also provides a controlled container lock (CCB). The results of CCB in which the nebulizer 1, the container 3 and / or the housing part 18 are blocked against further use or actuation with the respective container 3,
    Petition 870190092754, of 17/09/2019, p. 31/50
    29/36 when the predetermined number of operations or uses has been reached or exceeded. In other words, when a predetermined number of doses has been removed or removed from the respective container 3, the CCB provided by the counter device 44 blocks the nebulizer 1 against use or further activation with the present container 3. In addition, the container 3, the respective housing part 18 and / or the counting device 44 (which are preferably inseparably connected or form an inseparable group of components) are blocked against reuse and / or reconnection with the nebuliser 1. Thus, an empty or used container 3 it is blocked against reuse and / or reconnection with the nebulizer 1.
    [00120] The interlocking part of housing 18 with nebulizer 1 is preferably released or unlocked when the CCB is reached or activated or vice versa.
    [00121] In the present embodiment, the CCB is carried out by means of the control element 50. The control element 50 is polarized to its locking position, preferably axially upwards, by the polarization part 51. For this purpose, the the polarization part 51 is preferably pre-tensioned and / or, respectively, pre-formed, for example, type V or curved, with its free ends, preferably in the downward direction in figure 12. The engagement part 52 maintains the control element 50 in the unlocked position shown in figure 10, in particular where the coupling part 42 abuts an axial face or the bottom part of the control element or ring 45.
    [00122] When the predetermined number of operations or uses has been reached or exceeded, the control member has been indexed, that is, the control ring 45 has been rotated, so that the control recess 47 reaches the control element 50 or coupling part 52. Then, the coupling part 52 can move axially to
    Petition 870190092754, of 17/09/2019, p. 32/50
    30/36 inside or through the control recess 47 and the control element 50 can move axially by the pressure force of the polarization part 51 so that the control element 50 moves from the unlocked position to the locking position shown in the dashed lines in figure 10. In this locking position, the control element 50 protrudes through the housing part 18 and / or axially extends to a respective recess 63, slit or similar, in the upper housing part 16 so that the housing part 18 is locked against rotation relative to the upper housing part 16, that is, so that nebulizer 1 can no longer be tensioned. This locking recess 63 is shown schematically in figure 13.
    [00123] The control element 50 or its engagement part 52 locks the control ring 45 against further rotation, because the engagement part 52 engages the control recess 52 in the locking position of the control element 50.
    [00124] The control element 50 is locked in its locked position, preferably blocking the part 53. The locking part 53 is maintained by the fixing part 54 in a pre-tensioned state compressed or radially, when the control element 50 is in the unlock position (lower axial position in figure 10). When the control element 50 is moved (in figure 10 axially upwards) to its locking position, the locking part 53 passes to the holding part 54 and can flex radially (here internally) and lock - for example, by coupling with or adjacent to the fastening part 54 - the control element 50 against axial downward movement, so that the control element 50 is locked in its locked position. This situation is shown in dashed lines in figure 10. However, other construction solutions are also possible.
    Petition 870190092754, of 17/09/2019, p. 33/50
    31/36 [00125] When the predetermined number of operations or uses has been reached, that is, in the unlocked state, the CCB is activated and nebulizer 1 is not blocked against further opening and nebulizer 1 is blocked against use or tensioning additional. In this unlocked state, the lower housing part 18 can be detached, together with the respective container 3 and the counter device 44. As already mentioned, the housing part 18 is preferably inseparable from the container 3 or vice versa. In addition, the counter device 44 is preferably inseparable from the container 3 and / or the housing of part 18 or vice versa. Preferably, the housing part 18 is maintained by an appropriate force or adjustment and force in the unlocked state in the housing so that it is not just falling down, but this force is not too high that can be overcome to remove the part from the accommodation 18.
    [00126] Next, a new housing part 18 can be connected together with a new container 3 and a new counter device 44 for nebulizer 1. Nebulizer 1 can be used additionally with the new container 3.
    [00127] The counter device 44 or its control element 50 may also have the additional function or reconnection characteristic of container 3 / the housing part 18 already used is prevented after the housing part 18 and the container 3 have been separated nebulizer 1, or after nebulizer 1 or its housing has been opened, at least partially. To achieve this additional function, the control member 50 can move from its unlocked position to its locked position in two steps.
    [00128] In the first stage, when the predetermined number of operations of the nebulizer 1 with the respective container 3 has been reached or exceeded, the control element 50 moves from its initial unlocking position and not directly to the final position of
    Petition 870190092754, of 17/09/2019, p. 34/50
    32/36 lock, but to an intermediate position. The control element 50 engages in this intermediate position for the locking recess 63 and is preferably restricted against the additional axial movement of the locking recess 63, or any other means. In this intermediate position, the fastening part 53 has not yet passed to the fastening part 54 (completely). Thus, the nebulizer 1 is already blocked against the subsequent use operation, in particular against tensioning or rotation of the lower housing part 18, by the control element 50 surrounding the locking recess 63.
    [00129] When the housing part 18 is separated from the nebulizer 1, the second step is performed. The control element 50 moves further axially to the locking position shown in figure 10, so that the fastening part 53 passes to the fastening part 54 and can flex radially, as shown by the dashed line. In this final position, the control element 50 protrudes axially more than in the intermediate position. This additional axial protrusion prevents the twin housing part 18 from being switched on again, because the control element 50 prevents the housing from completely closing, in particular, the previously used and previously insulated housing part 18 can be pushed over the part internal 17 (again) completely. Thus, the counter device 44 and / or the control element 50 also prevent reconnection or reuse of the housing part 18 already used and / or container 3 already used with the nebulizer 1.
    [00130] Nebulizer 1 or monitoring device 23 provides a live extension lock (LSB) when the total number of operations or uses of nebulizer 1 has reached or exceeded the predetermined value (LSB value). The LSB is carried out in this mode by the locking spring 58, which finally blocks the nebulizer 1 against additional use, in particular against additional tensioning 870190092754, of 9/17/2019, p. 35/50
    33/36 national.
    [00131] As long as an LSB value has not been reached or exceeded, the monitoring device 23 does not block nebulizer 1 against further use. Therefore, nebulizer 1 can be used with multiple containers 3, for example, 2, 3, 4 or 5 containers 3, one after the other until the LSB value is reached or exceeded and nebulizer 1 is locked against further use.
    [00132] In the present modality, the axial position of the pilot 56 or an associated visualization mark or corresponds to them for the total number of operations or uses of nebulizer 1 and / or the number of containers 3 used with nebulizer 1 and can be made visible to the user (for example, the lower housing part 18 is preferably transparent, so that the pilot 56 is directly visible from the outside in the present embodiment).
    [00133] The monitoring device 23 can present or indicate the number of operations or use already carried out or that still remain. In addition, the monitoring device 23 can display or indicate the number of containers 3 that have already been used or that can still be used.
    [00134] In contrast, the counter device 44 counts only the number of operations or uses of the nebulizer 1 with the respective container 3. The rotational position of the control element or ring 45 corresponds to this number and can be made visible to a user ( not shown), if desired.
    [00135] The counter device 44 can present or indicate the number of operations or uses of the nebulizer 1 with the respective container 3 already carried out or that is still possible.
    [00136] The counter device 44 and / or the monitoring device 23 can indicate or display the respective number of digits and / or any other type of marking, such as a color code or
    Petition 870190092754, of 17/09/2019, p. 36/50
    34/36 change, letters or similar.
    [00137] Due to the inseparable interconnection of the container 3 with the housing part 18, the housing part 18 has to be replaced each time the container 3 is replaced.
    [00138] Preferably, the counter device 44 consists of only up to two pairs, here the control ring 45 and the control member 50.
    [00139] The control ring 45 is preferably molded and / or made of plastic.
    [00140] The control element 50 is preferably made of a stamping part or folded or unitary and / or metal, in particular steel or spring steel.
    [00141] Generally, it should be noted that, in the proposed nebulizer, a container 3 can preferably be inserted, in the nebulizer
    1. Therefore, container 3 is preferably a separate component. However, the container 3 can theoretically be formed directly by the nebulizer 1 or its housing part 18 or otherwise it can be integrated in the nebulizer 1 or its housing part 18.
    [00142] As already mentioned, the individual characteristics, aspects and / or principles of the described modalities can also be combined with each other, as desired and can be used in particular in the nebulizer according to figures 1 and 5, but also in similar or different nebulizers.
    [00143] Unlike standalone equipment or as the proposed nebulizer 1 is preferably designed to be portable and in particular, it is a mobile hand operated device.
    [00144] The proposed solution can, however, be used not only in the nebulizer 1 specifically described here, but also in other nebulizers or inhalers, powder inhalers, for example, or the
    Petition 870190092754, of 17/09/2019, p. 37/50
    35/36 called metered dose inhalers.
    [00145] Preferably, fluid 2 is a liquid, as already mentioned, especially an aqueous pharmaceutical formulation. However, it can also be another pharmaceutical formulation, a suspension or the like.
    [00146] According to an alternative embodiment, fluid 2 may also comprise particles or powder. In this case, instead of the expulsion nozzle 12, some other type of delivery device can be provided, especially the expulsion opening (not shown) or a feeding channel (not shown) to supply fluid to, or powder or similar, into the plug 13. The optional air supply opening 15 then serves to supply ambient air, preferably in parallel, so as to allow general or air flow with a volume sufficient to breathe or inhale through the shutter 13.
    [00147] If necessary, fluid 2 can also be atomized using a propellant gas.
    [00148] Preferred ingredients and / or formulations of fluid 2 preferably medicament are listed in particular in WO 2009/047173 A2, which is described herein incorporated by reference. As already indicated, these can be aqueous or non-aqueous solutions, mixtures, formulations containing ethanol or solvent-free, or the like.
    Listing of reference numerals
    1 nebulizer 33 locking arm 2 fluid 34 ventilation holes 3 container4 bag 35 fixing means36 support element 5 pressure generator6 support 36th final part37 locking element
    Petition 870190092754, of 17/09/2019, p. 38/50
    36/36
    7 spring unit 37th final part 8 locking element 37b drive part 9 conduction pipe 38 base 10 non-return valve 39 spring part 11 pressure chamber 40 fixing part 12 nozzle 41 edge 13 shutter 42 control member 14 aerosol 43 ring 15 air source opening 44 counter device 16 piece of upper housing 45 control ring 17 inner part 46 teeth 17th inside top 47 control recess 17b bottom part b inside 48 unlock recess 18 housing part (bottom) 49 saw 19 retaining element 50 control element 20 spring 51 part of polarization 21 container base 52 part of engagement 22 perforating element 53 lock part 23 mounting device 54 support part 24 fluid outlet 55 threaded shaft 25 first close 56 pilot 26 second lock 57 drive part 27 closing part 58 lock spring 28 flange 59 cylindrical gear 29 driving lock 60 cylindrical gear 30 fixing member 61 lock member 31 sealing clip 62 guiding surface 32 lock recess 63 lock recess
    Petition 870190092754, of 17/09/2019, p. 39/50
    权利要求:
    Claims (15)
    [1]
    1. Nebulizer (1) for a fluid (2) comprising an insertable container (3) containing the fluid (2), wherein the nebulizer (1) comprises a counter device (44) for counting operations of the nebulizer (1) , wherein the nebulizer (1) can be opened to replace the container (3), characterized by the fact that the counter device (44) comprises a control means for controlling the blocking of the nebulizer opening (1) in such a way that the counter device (44) blocks the opening of the nebulizer (1) until a predetermined number of operations of the nebulizer (1) with the container (3) has been reached or exceeded and unblocks the opening of the nebulizer (1) when the preset number -determined number of operations has been reached or exceeded.
    [2]
    2. Nebulizer according to claim 1, characterized by the fact that the nebulizer (1) comprises a housing part (18) that can be separated or opened to replace the container (3).
    [3]
    3. Nebulizer, according to claim 2, characterized by the fact that the nebulizer (1) or the counter device (44) is constructed in such a way that the housing part (18) must be replaced each time the container ( 3) is replaced.
    [4]
    Nebulizer, according to claim 2 or 3, characterized by the fact that the container (3) is inseparable from the housing part (18).
    [5]
    5. Nebulizer according to claim 4, characterized by the fact that the nebulizer (1) or the counter device (44) is constructed in such a way that the housing part (18) has an empty or used container (3) it is blocked against reuse and / or reconnection with the nebulizer (1).
    [6]
    6. Nebulizer, according to any of the claims
    Petition 870190092754, of 17/09/2019, p. 40/50
    2/3 cations 2 to 5, characterized by the fact that the nebulizer (1) or the housing part (18) comprises a fixing means (35) to support the container (3) in the housing part (18) inseparably, wherein the container (3) is movable back and forth within the nebulizer (1) and / or in relation to the housing part (18) during fluid conduction (2), pressure generation and / or nebulization.
    [7]
    Nebulizer according to any one of claims 2 to 6, characterized in that the counter device (44) connects the housing part (18) with the nebulizer (1) until the predetermined number of operations has been reached or exceeded.
    [8]
    Nebulizer according to any one of claims 1 to 7, characterized in that the counting device (44) or part of it is inseparable from the container (3), and / or that the counting device (44) must be replaced, together with the container (3), and / or the counter device (44) counts only nebulizer operations (1) with a single container (3).
    [9]
    Nebulizer according to any one of claims 1 to 8, characterized in that the nebulizer (1) comprises a monitoring device (23) for counting the total number of operations of the nebulizer (1), in particular with multiple containers (3).
    [10]
    10. Nebulizer, according to claim 9, characterized by the fact that the monitoring device (23) blocks the nebulizer (1) against further operation or use when the total number of operations has reached or exceeded a predetermined value.
    [11]
    11. Nebulizer according to claim 9 or 10, characterized by the fact that the monitoring device (23) activates the counting device (44), in particular, in which the counting device (44) can be separated from the monitoring device
    Petition 870190092754, of 17/09/2019, p. 41/50
    3/3 (23) and can be replaced.
    [12]
    Nebulizer according to any one of claims 1 to 11, characterized in that the control means, in particular a rotating control ring (45), blocks an associated container (3) or housing part (18) against subsequent additional use and / or reconnection to the nebulizer (1).
    [13]
    Nebulizer according to any one of claims 1 to 12, characterized in that the control means comprises an axial recess (47) so that the control means can be locked by engaging the recess (47) and / or that an associated control element (50) may surround this recess (47) to block the nebulizer (1), respectively, when the predetermined number of operations has been reached or exceeded.
    [14]
    Nebulizer according to any one of claims 1 to 13, characterized in that the nebulizer (1) is blocked in the shape adjustment mode, in particular by the counter device (44), until the predetermined number of operations has been reached or exceeded.
    [15]
    Nebulizer according to any one of claims 1 to 14, characterized in that the nebulizer (1) is constructed as an inhaler, in particular for the treatment of medical aerosol.
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    OA16315A|2015-04-24|Nebulizer.
    同族专利:
    公开号 | 公开日
    CN104225735B|2018-12-07|
    HK1175418A1|2013-07-05|
    AR079154A1|2011-12-28|
    AP3141A|2015-02-28|
    MA33755B1|2012-11-01|
    JP5715640B2|2015-05-13|
    CN102686260A|2012-09-19|
    PE20130036A1|2013-02-03|
    IL219088A|2016-04-21|
    CO6551692A2|2012-10-31|
    EA201200775A1|2012-12-28|
    EA026241B1|2017-03-31|
    UA107097C2|2014-11-25|
    CN102686260B|2014-10-01|
    US20110290239A1|2011-12-01|
    US9724482B2|2017-08-08|
    WO2011064164A1|2011-06-03|
    CA2781792C|2019-04-02|
    ECSP12011986A|2012-07-31|
    TN2012000245A1|2013-12-12|
    AU2010323220A1|2012-05-03|
    CL2012001359A1|2012-11-30|
    KR20120115278A|2012-10-17|
    CA2781792A1|2011-06-03|
    BR112012012475A8|2016-10-04|
    NZ599295A|2014-06-27|
    UY33054A|2011-06-30|
    KR101782306B1|2017-09-27|
    CN104225735A|2014-12-24|
    EP2504052A1|2012-10-03|
    AP2012006207A0|2012-04-30|
    AU2010323220B2|2015-04-23|
    MX2012005961A|2012-06-14|
    TW201129399A|2011-09-01|
    IL219088D0|2012-06-28|
    BR112012012475A2|2016-04-12|
    JP2013512015A|2013-04-11|
    SG181050A1|2012-07-30|
    ZA201202598B|2012-12-27|
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    法律状态:
    2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-07-23| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-01-14| B09A| Decision: intention to grant|
    2020-03-03| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/11/2010, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    EP09014680|2009-11-25|
    EP09014680.4|2009-11-25|
    PCT/EP2010/067902|WO2011064164A1|2009-11-25|2010-11-22|Nebulizer|
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